Is Epithalon the same as Epitalon?

Yes — Epithalon and Epitalon are alternate spellings of the same Khavinson tetrapeptide (Ala-Glu-Asp-Gly). The Russian-derived name Epitalon is sometimes preferred in older literature.

Why these three compounds together?

They target three independent hallmarks of aging — telomere length (Epithalon), NAD+/sirtuin signaling (NAD+), and redox balance (Glutathione) — without pathway overlap. Researchers studying multi-mechanism interventions can probe each axis cleanly.

What's the purity spec?

All three compounds are HPLC verified at ≥98% purity with mass-spectrometry confirmation. Individual COAs are included.

Longevity & Cellular Protocol

Aging biology and mitochondrial research

Overview

Epithalon, NAD+, and Glutathione — three independent aging-biology research axes: telomerase, sirtuin substrate, and redox homeostasis.

What's in This Stack

Each compound ships individually with its own Certificate of Analysis.

Epithalon 10mg — The telomere peptide — synthetic tetrapeptide that directly activates telomerase (hTERT), extends lifespan by 24% in model organisms, and restores pineal melatonin production. — $78.00 USD
NAD+ 500mg — The cellular energy currency coenzyme — NAD+ levels decline 50% with aging, impairing sirtuins, DNA repair, and mitochondrial function. Research-grade 500mg for NAD+ restoration protocols. — $118.00 USD
Glutathione 200mg — The master antioxidant tripeptide — GSH directly neutralizes ROS, regenerates vitamins C and E, and supports immune function. Injectable 200mg format for rapid systemic delivery research. — $70.00 USD

Research Rationale

Cellular aging is multi-causal — telomere shortening, NAD+ decline, and redox imbalance are three of the most-studied independent contributors. Hitting all three with characterized research compounds lets researchers explore mechanism interactions in vitro and in animal models without confounding the readout with broad-spectrum tools.

Synergistic Mechanism

The three compounds work on non-overlapping pathways: Epithalon (Ala-Glu-Asp-Gly) is studied for its activation of telomerase activity in somatic cells, NAD+ is a substrate for sirtuin family deacetylases (SIRT1-7) and PARP enzymes that depend on NAD+ for DNA-damage response, and reduced Glutathione is the primary cellular antioxidant maintaining the redox state. Together they cover three of the canonical "hallmarks of aging."

Protocol Details

Components: Epithalon (10mg) + NAD+ (500mg) + Glutathione (200mg)
Storage: Lyophilized at -20°C. Reconstituted at 2-8°C, use within 30 days
Verification: Each compound independently HPLC verified ≥98% purity
Documentation: Individual COA for each compound included

Key References

Epithalon induces telomerase activity in human somatic cells — Khavinson et al., 2003
NAD+ decline with age and sirtuin pathway implications — Imai & Guarente, 2014
Glutathione homeostasis and the redox theory of aging — Jones, 2008
Geroprotector compound stacking in C. elegans longevity studies — Moskalev et al., 2016

Frequently Asked Questions

Is Epithalon the same as Epitalon?: Yes — Epithalon and Epitalon are alternate spellings of the same Khavinson tetrapeptide (Ala-Glu-Asp-Gly). The Russian-derived name Epitalon is sometimes preferred in older literature.
Why these three compounds together?: They target three independent hallmarks of aging — telomere length (Epithalon), NAD+/sirtuin signaling (NAD+), and redox balance (Glutathione) — without pathway overlap. Researchers studying multi-mechanism interventions can probe each axis cleanly.
What's the purity spec?: All three compounds are HPLC verified at ≥98% purity with mass-spectrometry confirmation. Individual COAs are included.