DSIP (Delta Sleep-Inducing Peptide) is a nonapeptide originally isolated from the venous blood of rabbits in slow-wave sleep. It's been studied for its ability to modulate delta-wave sleep architecture and as a probe for sleep-stage neuropharmacology.

How is Epithalon related to sleep?

Epithalon's research applications include pineal gland physiology and melatonin synthesis. Because melatonin is the master regulator of the circadian cycle, Epithalon is studied for its indirect effects on sleep timing and circadian phase.

Both compounds are HPLC verified at ≥98% with mass-spec confirmation. Individual COAs are included.

Sleep & Recovery Protocol

Circadian peptides and recovery research

Overview

DSIP + Epithalon. Sleep-state EEG modulation paired with the upstream pineal-melatonin axis. Two windows on circadian biology.

What's in This Stack

Each compound ships individually with its own Certificate of Analysis.

DSIP 5mg — The original sleep neuropeptide — a thalamus-derived nonapeptide inducing delta slow-wave sleep, normalizing HPA stress reactivity, and demonstrating unique antioxidant and adaptogenic properties. — $55.00 USD
Epithalon 10mg — The telomere peptide — synthetic tetrapeptide that directly activates telomerase (hTERT), extends lifespan by 24% in model organisms, and restores pineal melatonin production. — $78.00 USD

Research Rationale

Sleep architecture and circadian regulation are studied at multiple levels: the immediate sleep-state EEG signal (DSIP literature focuses on delta-wave/slow-wave sleep), and the upstream pineal-melatonin axis that governs the diurnal cycle (Epithalon's primary research target). Combining the two gives researchers two non-overlapping windows on circadian biology.

Synergistic Mechanism

DSIP was identified in 1977 as a delta-wave-inducing peptide isolated from rabbit cerebral venous blood. Its primary research applications are in sleep-state EEG modulation and stress-response physiology. Epithalon is the Khavinson tetrapeptide that has been studied extensively for its effects on the pineal gland's melatonin synthesis machinery and downstream circadian regulation. The two peptides act at fundamentally different levels of the sleep system, making them complementary tools.

Protocol Details

Components: DSIP (5mg) + Epithalon (10mg)
Storage: Lyophilized at -20°C. Reconstituted at 2-8°C, use within 30 days
Verification: Each compound independently HPLC verified ≥98% purity
Documentation: Individual COA for each compound included

Key References

DSIP: isolation, characterization, and sleep-modulating activity — Schoenenberger & Monnier, 1977
Epithalon and pineal melatonin synthesis — Khavinson et al., 2002
Delta-wave sleep and recovery physiology — Tononi & Cirelli, 2014
Khavinson peptides in geroprotective and circadian research — Khavinson et al., 2015

Frequently Asked Questions

What is DSIP?: DSIP (Delta Sleep-Inducing Peptide) is a nonapeptide originally isolated from the venous blood of rabbits in slow-wave sleep. It's been studied for its ability to modulate delta-wave sleep architecture and as a probe for sleep-stage neuropharmacology.
How is Epithalon related to sleep?: Epithalon's research applications include pineal gland physiology and melatonin synthesis. Because melatonin is the master regulator of the circadian cycle, Epithalon is studied for its indirect effects on sleep timing and circadian phase.
What purity spec?: Both compounds are HPLC verified at ≥98% with mass-spec confirmation. Individual COAs are included.